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On the Antimicrobial and Hemolytic Activities of Amphiphilic β ‐Peptides
Author(s) -
Arvidsson Per I.,
Frackenpohl Jens,
Ryder Neil S.,
Liechty Brigitta,
Petersen Frank,
Zimmermann Heidrun,
Camenisch Gian P.,
Woessner Ralph,
Seebach Dieter
Publication year - 2001
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20011001)2:10<771::aid-cbic771>3.0.co;2-#
Subject(s) - amphiphile , antimicrobial , chemistry , antimicrobial peptides , combinatorial chemistry , microbiology and biotechnology , biochemistry , organic chemistry , biology , copolymer , polymer
Not generally harmful: The antimicrobial and hemolytic activity of amphiphilic β ‐homo ( β ‐H) peptides with the general formula H‐( β ‐HAla‐ β ‐HLys‐ β ‐HPhe)‐OH (see schematic representation) were investigated to unravel their potential for applications in medicinal chemistry. Only moderate activities were found for some of the peptides tested, critically depending on the side‐chain composition of the amphiphilic helix.