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PARP‐1: A Regulator of Genomic Stability Linked with Mammalian Longevity
Author(s) -
Bürkle Alexander
Publication year - 2001
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20011001)2:10<725::aid-cbic725>3.0.co;2-3
Subject(s) - poly adp ribose polymerase , longevity , genome instability , polymerase , biology , regulator , dna repair , ribose , dna damage , enzyme , genome , dna , genetics , microbiology and biotechnology , biochemistry , chemistry , gene
Guardian of the genome: Covalent modification of proteins with poly(ADP‐ribose) (see picture), catalysed by the enzyme poly(ADP‐ribose) polymerase‐1 (PARP‐1), is a rapid cellular response to DNA damage and contributes to genome stabilization in cells under genotoxic stress. Interestingly, the capacity of lymphocytes to produce poly(ADP‐ribose) is correlated with the life span of mammalian species, thus suggesting a functional role for PARP‐1 in longevity.