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Electroactive Monolayer Substrates that Selectively Release Adherent Cells
Author(s) -
Yeo WoonSeok,
Hodneland Christian D.,
Mrksich Milan
Publication year - 2001
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20010803)2:7/8<590::aid-cbic590>3.0.co;2-d
Subject(s) - substrate (aquarium) , monolayer , ligand (biochemistry) , adhesion , biophysics , chemistry , cell adhesion , cell , receptor , combinatorial chemistry , nanotechnology , materials science , biochemistry , biology , organic chemistry , ecology
A dynamic substrate that can selectively release immobilized ligands—even when multiple ligands are presented—has been prepared. These substrates can regulate, in real‐time, specific receptor–ligand interactions between a cell and the substrate to which it is attached. The picture shows that, after treatment, the dynamic substrate (right) has no cells attached to the surface, while the control surface (left) is still evenly covered with attached cells. This method provides a new approach to investigate the chemical biology of cell adhesion and migration.