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Sorting of Preproteins into Mitochondria
Author(s) -
Krimmer Thomas,
Geissler Andreas,
Pfanner Nikolaus,
Rassow Joachim
Publication year - 2001
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20010803)2:7/8<505::aid-cbic505>3.0.co;2-t
Subject(s) - mitochondrion , cytosol , microbiology and biotechnology , biology , computational biology , chemistry , biochemistry , enzyme
Sorted out! The proteins of mitochondria are provided by two different genetic systems. Following synthesis in the mitochondrial matrix or in the cytosol, they are specifically sorted into four mitochondrial compartments. The machineries, including the TOM complex (see picture), that direct the newly synthesized preproteins to their functional locations have been identified and are now studied in their molecular details.