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RNA Interference and Small Interfering RNAs
Author(s) -
Tuschl Thomas
Publication year - 2001
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20010401)2:4<239::aid-cbic239>3.0.co;2-r
Subject(s) - rna silencing , rna interference , small interfering rna , trans acting sirna , rna , biology , rnase p , rna induced transcriptional silencing , microbiology and biotechnology , computational biology , chemistry , genetics , gene
Double‐stranded RNA (dsRNA) activates the sequence‐specific degradation of homologous mRNAs in animal and plant cells by a process known as RNA interference (RNAi). The mediators of mRNA degradation are 21–23‐nt small interfering ribonucleoprotein particles (siRNPs) which are produced from dsRNA by an RNase III‐like processing reaction (see schematic picture). RNAi has rapidly become an invaluable tool for functional genomics and siRNAs are promising candidates for future biomedical applications.