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Designed Prostaglandins with Neurotrophic Activities
Author(s) -
Furuta Kyoji,
Tomokiyo Keiichiro,
Satoh Takumi,
Watanabe Yasuyoshi,
Suzuki Masaaki
Publication year - 2000
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20001117)1:4<283::aid-cbic283>3.0.co;2-o
Subject(s) - neurotrophin , neurite , neurotrophic factors , in vivo , programmed cell death , prostaglandin , stimulation , chemistry , neuroscience , pharmacology , microbiology and biotechnology , biology , biochemistry , in vitro , apoptosis , receptor
Improved stability and unprecedented biological activities —stimulation of neurite outgrowth and prevention of cell death—are exhibited by the novel Δ 7 ‐prostaglandin A 1 analogues 1 and 2 . The synthesis of these neurotrophic compounds opens the way to the design of prostaglandins that can be used as probes for in vivo brain research and to the development of chemotherapeutic agents for the treatment of neurodegenerative diseases.