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Translational Termination Not Yet at Its End
Author(s) -
Connell Sean R.,
Nierhaus Knud H.
Publication year - 2000
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20001117)1:4<250::aid-cbic250>3.0.co;2-b
Subject(s) - mimicry , transfer rna , peptidyl transferase , ribosome , translation (biology) , schematic , p site , biology , computational biology , chemistry , genetics , rna , messenger rna , ecology , electronic engineering , engineering , gene
A tRNA‐like mimicry is suggested by the recently solved X‐ray crystal structure of the translational termination factor eRF1 (see schematic ribbon‐plot presentation) in the sense that eRF1 has the overall shape and dimensions of a tRNA molecule. This mimicry provides a means for the interaction of eRF1 with the decoding center and the peptidyl‐transferase center, two essential and conserved functional sites on the ribosome.