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Synthesis of Characteristic H‐Ras Lipopeptides by Employing Noble‐Metal‐, Acid‐, and Reduction‐Labile Blocking Groups
Author(s) -
Kadereit Dieter,
Waldmann Herbert
Publication year - 2000
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20001002)1:3<200::aid-cbic200>3.0.co;2-4
Subject(s) - blocking (statistics) , noble metal , chemistry , combinatorial chemistry , metal , base (topology) , stereochemistry , organic chemistry , mathematics , mathematical analysis , statistics
Acid‐ and base‐labile H‐Ras lipopeptides (see picture) can be efficiently synthesized by the combined use of the noble‐metal‐sensitive allyloxycarbonyl (Aloc) group, the acid‐labile tert ‐butyl ester function, and the reductively removable S‐ t Bu thiol‐blocking group, which were all mutually compatible (orthogonal).