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The Chemistry and Biology of Discodermolide
Author(s) -
Kalesse Markus
Publication year - 2000
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20001002)1:3<171::aid-cbic171>3.0.co;2-d
Subject(s) - chemistry , chemical biology , computational biology , nanotechnology , biology , biochemistry , materials science
The major obstacle in the potential medicinal use of discodermolide (1) —its insufficient supply from natural sources—might be eliminated by the recently accomplished total syntheses of this antitumour agent. In contrast to paclitaxel, discodermolide is active even against multidrug‐resistant cells; it also has a significantly higher affinity to the tubulin‐binding site.