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Synthesis and Biological Evaluation of Aza‐Epothilones
Author(s) -
Schinzer Dieter,
Altmann KarlHeinz,
Stuhlmann Friedrich,
Bauer Armin,
Wartmann Markus
Publication year - 2000
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/1439-7633(20000703)1:1<67::aid-cbic67>3.0.co;2-i
Subject(s) - epothilones , epothilone , scaffold , modular design , chemistry , stereochemistry , combinatorial chemistry , computational biology , biology , computer science , programming language
A macrolactam scaffold rather than the natural macrolactone scaffold is the characteristical feature of a new class of epothilone A analogues (see picture). These aza‐epothilones were synthesized with a modular approach in pure form and excellent yields, and their biological properties were evaluated.