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Recognition and Selective Transport of Nucleic Acid Components through Molecularly Imprinted Polymeric Membranes
Author(s) -
Yoshikawa Masakazu,
Izumi Junichiro,
Guiver Michael D.,
Robertson Gilles P.
Publication year - 2001
Publication title -
macromolecular materials and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 96
eISSN - 1439-2054
pISSN - 1438-7492
DOI - 10.1002/1439-2054(20010101)286:1<52::aid-mame52>3.0.co;2-r
Subject(s) - membrane , molecularly imprinted polymer , molecular recognition , molecular imprinting , selective adsorption , polymer , molecule , materials science , combinatorial chemistry , selectivity , guanosine , polystyrene , adsorption , chemistry , organic chemistry , biochemistry , catalysis
To induce “molecular memory” in a membrane substrate at the same time that the membrane was prepared from its polymer solution, an alternative molecular imprinting technique was applied. Upon membrane formation, a “molecular memory” of the imprint molecule is retained by the formed membrane that recognizes or favors interaction with print molecule analogues. In the present study, polystyrene resin bearing a tetrapeptide derivative, a derivative of natural polymer, and an entirely non‐chiral synthetic polymer were adopted as candidate materials to form molecular recognition sites. 9‐Ethyladenine was adopted as a print molecule. These molecularly imprinted polymeric membranes recognized and adsorbed adenosine ( As ), which is an analogue of the print molecule, in preference to guanosine ( Gs ) from As / Gs mixtures. However Gs was permeated in preference to As contrary to adsorption selectivity, possibly because of the relatively high affinity between As and the membrane.