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Regioselective acylation of flavonoids catalyzed by lipase in low toxicity media
Author(s) -
Kontogianni Athina,
Skouridou Vasso,
Sereti Vasiliki,
Stamatis Haralambos,
Kolisis Fragiskos N.
Publication year - 2001
Publication title -
european journal of lipid science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.614
H-Index - 94
eISSN - 1438-9312
pISSN - 1438-7697
DOI - 10.1002/1438-9312(200110)103:10<655::aid-ejlt655>3.0.co;2-x
Subject(s) - candida antarctica , acylation , chemistry , lipase , naringin , organic chemistry , regioselectivity , rutin , flavonoid , catalysis , triacylglycerol lipase , enzyme , chromatography , antioxidant
Flavonoid fatty esters were prepared by acylation of flavonoids (rutin and naringin) by fatty acids (C8, C10, C12), catalyzed by immobilized lipase from Candida antarctica in various solvent systems. The reaction parameters affecting the conversion of the enzymatic process, such as the nature of the organic solvent and acyl donor used, the water activity (a w ) of the system, as well as the acyl donor concentration have been investigated. At optimum reaction conditions, the conversion of flavonoids was 50—60% in t ert‐butanol at a w less than 0.11. In all cases studied, only flavonoid monoester was identified, which indicates that this lipase‐catalyzed esterification is regioselective.