Open AccessHealth examination results and work environment factors affecting urinary 8‐hydroxy‐2′‐deoxyguanosine levels
Author(s) -
Watanabe Sintaroo,
Li YunShan,
Kawasaki Yuya,
Ootsuyama Yuko,
Kawai Kazuaki
Publication year - 2021
Publication title -
journal of occupational health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 59
ISSN - 1348-9585
DOI - 10.1002/1348-9585.12210
Subject(s) - oxidative stress , urinary system , medicine , national health and nutrition examination survey , deoxyguanosine , 8 hydroxy 2' deoxyguanosine , urine , physiology , biomarker , endocrinology , environmental health , biochemistry , chemistry , dna oxidation , oxidative damage , population
Objective Oxidative stress is considered to cause lifestyle‐related diseases, including cancer. Urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) is widely analyzed as an oxidative stress marker. We extensively scrutinized the relationships between 8‐OHdG levels and lifestyle choices as carcinogenic factors. Methods In this study, we investigated health examination results and working conditions affecting urinary 8‐OHdG levels in 503 male workers. Results The urinary 8‐OHdG level was positively associated with high blood sugar and leanness in smokers. In addition, urinary 8‐OHdG tended to increase with organic solvent or hydrochloric acid exposure, as well as long working hours. On the other hand, the urinary 8‐OHdG level was negatively associated with high plasma LDL‐cholesterol levels in non‐smokers and anemia. Conclusion According to the results, anemia decreased the oxidative stress, regardless of smoking status, while leanness or high blood sugar increased the oxidative stress in smokers, and the presence of plasma cholesterol contributed to the lower oxidative stress in non‐smokers. Certain types of occupational exposure may cause oxidative stress. The measurement of urinary 8‐OHdG at annual health checks may be a useful biomarker for preventing lifestyle‐ and work‐related diseases.