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Novel polysaccharide hydrogels: characterization and properties
Author(s) -
Magnani Agnese,
Rappuoli Roberto,
Lamponi Stefania,
Barbucci Rolando
Publication year - 2000
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/1099-1581(200008/12)11:8/12<488::aid-pat995>3.0.co;2-5
Subject(s) - self healing hydrogels , materials science , polysaccharide , adhesion , chemical engineering , swelling , polymer chemistry , scanning electron microscope , polymer , organic chemistry , chemistry , composite material , engineering
New chemical hydrogels, potentially suitable for biomedical applications, have been synthesized and characterized by 13 C NMR, and FT‐IR spectroscopy. The polysaccharide components of these hydrogels are hyaluronane, alginate and carboxymethylcellulose, while the novel cross‐linking procedure consists of activating the carboxylate moieties by 2‐chloro‐1‐methylpyridinium iodide CMPJ and using 1,3‐diaminopropane as a chemical bridge. Varying the amount of CMPJ three series of hydrogels were obtained with different cross‐linking degrees (5, 50, 100%). Their percentages were determined by 13 C NMR and FT‐IR analysis. The morphology of the gels was studied by scanning electron‐microscopy and the pore sizes were determined in order to find a relationship with the swelling properties. Cell adhesion, using human hepatocytes, and platelet adhesion studies on the different series of cross‐linked compounds allowed us to envisage their utilization as extracellular matrix materials and cardiovascular biomaterials. Copyright © 2000 John Wiley & Sons, Ltd.