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Hydrolytic degradation of polyester–polyether block copolymer based on polycaprolactone/poly(ethylene glycol)/polylactide
Author(s) -
Chen Hongli,
Bei Jianzhong,
Wang Shenguo
Publication year - 2000
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/1099-1581(200004)11:4<180::aid-pat965>3.0.co;2-c
Subject(s) - copolymer , polycaprolactone , ethylene glycol , materials science , polyester , gel permeation chromatography , molar mass , polymer chemistry , differential scanning calorimetry , ethylene oxide , hydrolysis , polymer , molar mass distribution , chemical engineering , organic chemistry , chemistry , composite material , physics , engineering , thermodynamics
Polyester–polyether block copolymers based on polycaprolactone/poly(ethylene glycol)/polylactide (PCEL) with various compositions were synthesized by direct copolymerization of ϵ‐caprolactone, L ‐lactide and PEG (6000) in the presence of stannous octoate at 130 ° C for 56 hr . The degradation behavior of the copolymers was investigated in a pH 7.4 phosphate buffer solution at 37 ±1 ° C . Various techniques such as weight, gel permeation chromatography, 1 H nuclear magnetic resonance, differential scanning calorimetry and X‐ray diffractometry were used to monitor the changes in water absorption, weight loss, molar mass, molar mass distribution, thermal properties and compositions. The results show that the hydrophilicity of copolymer was enhanced with increasing poly(ethylene oxide) content, which led to the PEG sequences fast release and an increase in weight loss of the copolymer. Bimodal chromatograms were detected in the degradation, which were attributed to the degradation mechanism of the partial crystalline polymer proceeding predominantly in amorphous zones. Copyright © 2000 John Wiley & Sons, Ltd.