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From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited
Author(s) -
Rihn Bertrand,
Saliou Claude,
Bottin Marie Claire,
Keith Gerard,
Packer Lester
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200102)15:1<76::aid-ptr747>3.0.co;2-o
Subject(s) - bark (sound) , traditional medicine , pharmacognosy , medicine , folk medicine , biology , ecology , biological activity , biochemistry , in vitro
The effect of French maritime pine bark extract (PBE) on the gene expression profile of HaCaT human keratinocytes was studied using high density filter arrays. The expression profile of both control and PBE‐treated cells was determined. Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses. Copyright © 2001 John Wiley & Sons, Ltd.