Premium
Antispasmodic activity of the fruits of Helicteres isora Linn.
Author(s) -
Pohocha Nazneen,
Grampurohit Nirmala D.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200102)15:1<49::aid-ptr729>3.0.co;2-e
Subject(s) - antispasmodic , diphenhydramine , traditional medicine , histamine , acetylcholine , in vivo , ileum , medicine , atropine , pharmacognosy , barium chloride , pharmacology , chemistry , biology , in vitro , biological activity , anesthesia , biochemistry , microbiology and biotechnology , organic chemistry
Fruits of Helicteres isora Linn., commonly called Murudsheng in India, are usually prescribed in the Indian traditional systems of medicine, especially in Ayurveda, for a variety of intestinal complaints. The antispasmodic activity was checked in vitro on guinea‐pig ileum against three spasmogens, acetylcholine, histamine and barium chloride. The IC 50 for each was determined. The activity was compared with standard antispasmodic agents, atropine and diphenhydramine hydrochloride. The activity was also studied in vivo by observing the gastrointestinal motility in mice using the marker technique and the ED 50 was calculated. Acute toxicity studies were conducted on mice using the method of Weil and the LD 50 was determined. The results indicated that the fruits possess very good antispasmodic activity. Copyright © 2001 John Wiley & Sons, Ltd.