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Activity of plant flavonoids against antibiotic‐resistant bacteria
Author(s) -
Xu HongXi,
Lee Song F.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200102)15:1<39::aid-ptr684>3.0.co;2-r
Subject(s) - myricetin , kaempferol , microbiology and biotechnology , flavones , staphylococcus epidermidis , quercetin , flavonols , luteolin , burkholderia , minimum inhibitory concentration , biology , isorhamnetin , chemistry , staphylococcus aureus , bacteria , traditional medicine , antibiotics , biochemistry , botany , medicine , genetics , antioxidant
Thirty eight plant‐derived flavonoids representing seven different structural groups were tested for activities against antibiotic‐resistant bacteria using the disc‐diffusion assay and broth dilution assay. Among the flavonoids examined, four flavonols (myricetin, datiscetin, kaempferol and quercetin) and two flavones (flavone and luteolin) exhibited inhibitory activity against methicillin‐resistant Staphylococcus aureus (MRSA). Myricetin was also found to inhibit the growth of multidrug‐resistant Burkholderia cepacia , vancomycin‐resistant enterococci (VRE) and other medically important organisms such as Klebsiella pneumoniae and Staphylococcus epidermidis . Myricetin was bactericidal to B. cepacia . The results of the radiolabel incorporation assay showed that myricetin inhibited protein synthesis by B. cepacia . The structure–activity relationship of these flavonoids is discussed. Copyright © 2001 John Wiley & Sons, Ltd.