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Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha .
Author(s) -
Moreira A. S.,
Spitzer V.,
Schapoval E. E. S.,
Schenkel E. P.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200012)14:8<638::aid-ptr681>3.0.co;2-q
Subject(s) - caffeic acid , rutin , chlorogenic acid , proline , chemistry , ethanol , aqueous solution , ethyl acetate , asteraceae , amino acid , pharmacognosy , traditional medicine , chromatography , biochemistry , organic chemistry , biological activity , botany , biology , in vitro , antioxidant , medicine
The aqueous and ethanol extracts from the leaves of Gochnatia polymorpha and further fractions obtained from the latter extract using solvents with increasing polarity, including its aqueous residue and the amino acid, 4‐hydroxy‐N‐methyl‐proline were investigated by carrageenin‐induced pedal oedema formation. It was shown that the aqueous and ethanol extracts and the ethyl acetate fraction demonstrated significant antiinflammatory activity. The chemical investigation of the latter fraction revealed the presence of caffeic acid, chlorogenic acid, 3‐0‐methylquercetin, hyperosid and rutin. The amino acid 4‐hydroxy‐N‐methyl‐proline, a nonprotein amino acid that has not been reported before in the Asteraceae was isolated as a major compound and identified by spectroscopic methods. Copyright © 2000 John Wiley & Sons, Ltd.