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Analgesic and antiinflammatory activities of an extract from Parkia biglobosa used in traditional medicine in the Ivory Coast
Author(s) -
Kouadio F.,
Kanko C.,
Juge M.,
Grimaud N.,
Jean A.,
N'Guessan Y. T.,
Petit J. Y.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200012)14:8<635::aid-ptr427>3.0.co;2-t
Subject(s) - parkia biglobosa , analgesic , traditional medicine , medicine , bark (sound) , pharmacognosy , folk medicine , pharmacology , biological activity , chemistry , biology , in vitro , botany , ecology , biochemistry , locust
In the Ivory coast, Parkia biglobosa (Mimosaceae) is used in traditional medicine as an analgesic drug, especially against dental pain. Of the three extracts obtained from the plant bark, the hexane fraction was studied to determine its analgesic and/or antiinflammatory activities. The results show that this extract possesses a marked analgesic activity when evaluated with the abdominal writhing test in mice, but, like paracetamol, was ineffective with the hot‐plate method, a feature suggesting a peripheral mechanism of action. This activity was accompanied by an antiinflammatory effect, somewhat weaker than the analgesic one. Copyright © 2000 John Wiley & Sons, Ltd.