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Clastogenic effect of ginger rhizome in mice
Author(s) -
Mukhopadhyay Madhumita J.,
Mukherjee Anita
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200011)14:7<555::aid-ptr659>3.0.co;2-j
Subject(s) - rhizome , traditional medicine , clastogen , pharmacognosy , zingiberaceae , medicine , biology , toxicity , genetics , micronucleus test , biological activity , in vitro
The present study focuses on the clastogenic effect of ginger rhizome. Crude aqueous extracts of ginger were gavaged at doses of 0.5, 1, 2, 5, 10 g/kg body weight and ginger oil (0.625, 1.250 and 2.50 ml/kg body weight) was administered by intraperitoneal injection to male mice. Chromosome damage was studied in a preparation made from bone marrow cells following colchicine injection to all mice and examination of the cells after pretreatment in hypotonic solution, fixation, air drying and staining in Giemsa solution. Attention is drawn to the weakness of the clastogenic activity expressed by the ginger extract. In comparison ginger oil gave a higher frequency of chromosomal aberrations. It is suggested therefore, that the extract may contain substance(s) that suppress clastogenesis in the bone marrow cells of mice. Copyright © 2000 John Wiley & Sons, Ltd.