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Myorelaxant and antispasmodic effects of the essential oil of Alpinia speciosa on rat ileum
Author(s) -
Bezerra Maria A. C.,
LealCardoso José H.,
CoelhodeSouza Andreli.,
Criddle David Neil,
Fonteles Manassés C.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200011)14:7<549::aid-ptr623>3.0.co;2-t
Subject(s) - antispasmodic , ileum , acetylcholine , essential oil , traditional medicine , pharmacognosy , jejunum , chemistry , pharmacology , biology , medicine , biological activity , in vitro , food science , biochemistry
The effects of the essential oil of Alpinia speciosa Schum (EOAS) on rat ileum were studied. EOAS (0.1–600 µg/mL) reversibly relaxed ileal basal tonus. Submaximal contractions induced by 60 m M KCl or acetylcholine were concentration dependently inhibited by EOAS with similar IC 50 values (∼ 44 and 48 µg/mL, respectively). These results show that EOAS possesses both relaxant and antispasmodic actions in the ileum. Copyright © 2000 John Wiley & Sons, Ltd.