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In vitro and in vivo activity of eugenol on human herpesvirus
Author(s) -
Benencia F.,
Courrèges M.C.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200011)14:7<495::aid-ptr650>3.0.co;2-8
Subject(s) - eugenol , cytotoxicity , in vitro , in vivo , herpesviridae , pharmacology , virology , chemistry , virus , biology , biochemistry , viral disease , microbiology and biotechnology , organic chemistry
Eugenol (4‐allyl‐1‐hydroxy‐2‐methoxybenzene) was tested for antiviral activity against HSV‐1 and HSV‐2 viruses. In vitro , it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti‐HSV effects of eugenol were 25.6 µg/mL and 16.2 µg/mL for HSV‐1 and HSV‐2 respectively, 250 µg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol–acyclovir combinations synergistically inhibited herpesvirus replication in vitro . Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model. Copyright © 2000 John Wiley & Sons, Ltd.