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Antioxidant action of extract of the traditional medicinal plant Rhazya stricta Decne. in rats
Author(s) -
Ali B. H.,
Alqarawi A. A.,
Bashir A. K.,
Tanira M. O.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200009)14:6<469::aid-ptr612>3.0.co;2-w
Subject(s) - traditional medicine , antioxidant , pharmacognosy , action (physics) , biology , botany , medicine , biological activity , biochemistry , in vitro , physics , quantum mechanics
Abstract The effects of a leaf extract of the traditional medicinal plant Rhazya stricta (0.25, 1.0 and 4.0 g/kg/day for 3 days) on reduced glutathione (GSH), lipid peroxidation (LP) and ascorbic acid (AA) concentrations in the liver and kidneys were studied in rats 24 h after the last dose. The plant extract, at a dose of 0.25 g/kg, did not significantly affect the concentrations of GSH, LP or AA in the liver or kidneys. At a dose of 1.0 g/kg, the plant extract significantly increased the GSH concentration in the liver, but did not affect the GSH concentration in the kidneys, or LP or AA in the liver or kidneys. The plant extract (4.0 g/kg) significantly increased the GSH and decreased LP peroxidation, but did not affect the AA concentrations in the liver and kidneys. It may be concluded that the R. stricta extract, at some of the doses used, has antioxidant actions in the rat. Copyright © 2000 John Wiley & Sons, Ltd.