Premium
Extract prepared from the bark of Cinnamomum cassia Blume prevents glutamate‐induced neuronal death in cultured cerebellar granule cells
Author(s) -
Shimada Yutaka,
Goto Hirozo,
Kogure Toshiaki,
Kohta Kazufumi,
Shintani Takahiro,
Itoh Takashi,
Terasawa Katsutoshi
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200009)14:6<466::aid-ptr614>3.0.co;2-z
Subject(s) - cinnamomum , cassia , glutamate receptor , granule (geology) , bark (sound) , programmed cell death , chemistry , pharmacology , biology , traditional medicine , biochemistry , medicine , apoptosis , paleontology , ecology , alternative medicine , receptor , pathology , traditional chinese medicine
We studied the protective effect of a water extract from the bark of Cinnamomum cassia Blume on glutamate‐induced neuronal death by MTT assay and its action on 45 Ca 2+ influx using cultured rat cerebellar granule cells. In a dose‐dependent manner, this extract (10 −5 –10 −4 g/mL) significantly protected against glutamate‐induced cell death and also inhibited glutamate‐induced 45 Ca 2+ influx. These results suggest that the bark of Cinnamomum cassia has a protective effect on glutamate‐induced neuronal death through the inhibition of Ca 2+ influx. Copyright © 2000 John Wiley & Sons, Ltd.