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Evaluation of the antimicrobial property of the stem bark of Picralima nitida (Apocynaceae)
Author(s) -
Fakeye T. O.,
Itiola O. A.,
Odelola H. A.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200008)14:5<368::aid-ptr615>3.0.co;2-x
Subject(s) - apocynaceae , antimicrobial , traditional medicine , ampicillin , gentamicin , biology , minimum inhibitory concentration , bark (sound) , antibiotics , bacteria , gram negative bacteria , botany , microbiology and biotechnology , medicine , escherichia coli , biochemistry , ecology , genetics , gene
The basic fraction (BF) of the methanol extract of the stem bark of Picralima nitida (family Apocynaceae) exhibited significant antimicrobial activity against a wide range of Gram‐positive bacteria and fungi, but limited activity against Gram‐negative bacteria. The BF had a similar minimum inhibitory concentration (MIC) for S. aureus to the control drug ampicillin, and lower MIC values against A. flavus and A. niger than those of tiaconazole. Values of the minimum bactericidal concentration (MBC) of the BF against microorganisms tested were generally much higher than those for the control drugs ampicillin and gentamicin. The results suggest that some constituents of the stem bark could be isolated and developed into effective antimicrobial agents. Copyright © 2000 John Wiley & Sons, Ltd.