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Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone
Author(s) -
Marshall Sarah J.,
Russell Peter F.,
Phillipson J. David,
Kirby Geoffrey C.,
Warhurst David C.,
Wright Colin W.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200008)14:5<356::aid-ptr636>3.0.co;2-z
Subject(s) - sierra leone , entamoeba histolytica , traditional medicine , plasmodium falciparum , medicinal plants , menispermaceae , pharmacognosy , biology , in vitro , malaria , botany , microbiology and biotechnology , medicine , biological activity , alkaloid , immunology , biochemistry , development economics , economics
Abstract Crude ethanol extracts of 18 medicinal plants from Sierra Leone, West Africa were examined for antiplasmodial activity against Plasmodium falciparum , using an in vitro microtest. Eleven of these extracts were also screened for in vitro antiamoebic activity against Entamoeba histolytica . Only one plant extract, Triclisia patens (Menispermaceae) showed significant antiplasmodial activity (IC 50 = 8 µg/mL). None of the plant extracts was effective against Entamoeba histolytica . Copyright © 2000 John Wiley & Sons, Ltd.