Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone | Zendy

Marshall Sarah J. | Zendy; Russell Peter F. | Zendy; Phillipson J. David | Zendy; Kirby Geoffrey C. | Zendy; Warhurst David C. | Zendy; Wright Colin W. | Zendy

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Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone

Author(s) -

Marshall Sarah J.,

Russell Peter F.,

Phillipson J. David,

Kirby Geoffrey C.,

Warhurst David C.,

Wright Colin W.

Publication year - 2000

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/1099-1573(200008)14:5<356::aid-ptr636>3.0.co;2-z

Subject(s) - sierra leone , entamoeba histolytica , traditional medicine , plasmodium falciparum , medicinal plants , menispermaceae , pharmacognosy , biology , in vitro , malaria , botany , microbiology and biotechnology , medicine , biological activity , alkaloid , immunology , biochemistry , development economics , economics

Crude ethanol extracts of 18 medicinal plants from Sierra Leone, West Africa were examined for antiplasmodial activity against Plasmodium falciparum , using an in vitro microtest. Eleven of these extracts were also screened for in vitro antiamoebic activity against Entamoeba histolytica . Only one plant extract, Triclisia patens (Menispermaceae) showed significant antiplasmodial activity (IC 50 = 8 µg/mL). None of the plant extracts was effective against Entamoeba histolytica . Copyright © 2000 John Wiley & Sons, Ltd.

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