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The effect of extracts of Cynomorium coccineum and Withania somnifera on gonadotrophins and ovarian follicles of immature Wistar rats
Author(s) -
AlQarawi A. A.,
AbdelRahman H. A.,
ElBadry A. A.,
Harraz F.,
Razig N. A.,
AbdelMagied E. M.
Publication year - 2000
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/1099-1573(200006)14:4<288::aid-ptr603>3.0.co;2-9
Subject(s) - folliculogenesis , withania somnifera , biology , antral follicle , follicular phase , endocrinology , ovary , medicine , body weight , ovarian follicle , andrology , oogenesis , oocyte , pathology , lactation , pregnancy , genetics , alternative medicine , embryo , microbiology and biotechnology
The effects of water extracts of Cynomorium coccineum and Withania somnifera on ovarian follicular development and serum levels of FSH and LH were studied in immature 17‐day‐old and 25‐day‐oldWistar rats. Water extracts of the plants were given to the animals per os in a dose of 47 mg/100 g body weight for 6 days. Serum levels of FSH and LH were measured by ELISA. Folliculogenesis was studied with a light microscope. In 25‐day‐old rats, extracts of both plants elicited significant changes in gonadotrophin levels coupled with a significant increase in ovarian weight and profound folliculogenesis. Numerous primary, secondary, tertiary and antral follicles were present. A distinct zona pellucida was not seen and the oocyte was often detached. In 17‐day‐old animals there was a significant increasein body weight but without significant changes in the ovarian weight and folliculogenesis. Copyright © 2000 John Wiley & Sons, Ltd.