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Misoprostol and congenital anomalies
Author(s) -
Brasil Rita,
Lutéscia Coelho Helena,
D'Avanzo Barbara,
La Vecchia Carlo
Publication year - 2000
Publication title -
pharmacoepidemiology and drug safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.023
H-Index - 96
eISSN - 1099-1557
pISSN - 1053-8569
DOI - 10.1002/1099-1557(200009/10)9:5<401::aid-pds527>3.0.co;2-1
Subject(s) - medicine , misoprostol , pregnancy , abortion , biology , genetics
Purpose — To evaluate the risk of having a baby with congenital anomalies in mothers who used misoprostol during pregnancy. Methods — Hospital‐based case – control study from Hospital Chateaubriand, Fortaleza, Brasil. Cases were 37 babies weighing less than 1500 g with congenital anomalies of various types, and the comparison group included 387 infants also weighing less than 1500 g, and without congenital anomalies. Results — The multivariate odds ratio of having a baby with congenital anomalies was 2.4 (95% confidence interval 1.0 – 6.2) in mothers who reported having used misoprostol compared with those who did not. Conclusions — Misoprostol use during pregnancy might be related to a broad spectrum of congenital anomalies in infants. Copyright © 2000 John Wiley & Sons, Ltd.