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Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI
Author(s) -
Payen JeanFrançois,
Briot Emmanuel,
Tropres Irène,
JulienDolbec Cécile,
Montigon Olivier,
Decorps Michel
Publication year - 2000
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/1099-1492(200011)13:7<384::aid-nbm655>3.0.co;2-v
Subject(s) - hypocapnia , contrast (vision) , cerebral blood volume , nuclear magnetic resonance , volume (thermodynamics) , blood volume , medicine , cardiology , nuclear medicine , cerebral blood flow , hypercapnia , physics , respiratory system , quantum mechanics , optics
We used steady‐state susceptibility contrast MRI to evaluate the regional cerebral blood volume (rCBV) response to hypocapnia in anesthetised rats. The rCBV was determined in the dorsoparietal neocortex, the corpus striatum, the cerebellum, as well as blood volume in extracerebral tissue (group 1). In addition, we used laser‐Doppler flow (LDF) measurements in the left dorsoparietal neocortex (group 2), to correlate changes in CBV and in cerebral blood flow. Baseline values, expressed as a percentage of blood volume in each voxel, were higher in the brain regions than in extracerebral tissue. Hypocapnia (P a CO 2 ≈ 25 mmHg) resulted in a significant decrease in CBV in the cerebellum (−17 ± 9%), in the corpus striatum (−15 ± 6%) and in the neocortex (−12 ± 7%), compared to the normocapnic CBV values (group 1). These changes were in good agreement with the values obtained using alternative techniques. No significant changes in blood volume were found in extracerebral tissue. The CBV changes were reversed during the recovery period. In the left dorsoparietal neocortex, the reduction in LDF (group 2) induced by hypocapnia (−21 ± 8%) was in accordance with the values predicted by the Poiseuille's law. We conclude that rCBV changes during CO 2 manipulation can be accurately measured by susceptibility contrast MRI. Copyright © 2000 John Wiley & Sons, Ltd. Abbreviations used: ANOVA analysis of variancceCBF cerebral blood flowCBV cerebral blood volumeCPMG Carr–Purcell–Meiboom–GillFiO 2 fractional inspired oxygenICP intracranial pressureLDF laser‐Doppler flowMABP mean arterial blood pressureMRI magnetic resonance imagingMTT mean transit timePaCO 2 arterial partial pressure of carbon dioxidePaO 2 arterial partial pressure of oxygenPET positron emission tomographyrCBV regional cerebral blood volumeSPECT single‐photon emission computed tomography