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Evaluation of carrier agents for hyperpolarized xenon MRI
Author(s) -
Venkatesh Arvind K.,
Zhao Lei,
Balamore Dilip,
Jolesz Ferenc A.,
Albert Mitchell S.
Publication year - 2000
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/1099-1492(200006)13:4<245::aid-nbm635>3.0.co;2-7
Subject(s) - liposome , xenon , in vivo , biocompatible material , chemistry , perfusion , suspension (topology) , aqueous suspension , emulsion , nuclear magnetic resonance , biomedical engineering , medicine , radiology , biochemistry , aqueous solution , organic chemistry , physics , microbiology and biotechnology , mathematics , homotopy , pure mathematics , biology
Several biocompatible carrier agents, in which xenon is highly soluble and has a long T 1 , were tested, and injected in living rats. These included saline, Intralipid suspension, perfluorocarbon emulsion and 129 Xe gas‐filled liposomes. The T 1 of 129 Xe in these compounds ranged from 47 to 116 s. Vascular injection of these carrier agents was tolerated well, encouraging their use for further experiments in live animals. In vivo spectra, obtained from gas‐filled liposomes and perfluorocarbon solutions, suggest that these carrier agents have potential for use in angiography and perfusion imaging. Copyright © 2000 John Wiley & Sons, Ltd.