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Intravenous delivery of hyperpolarized 129 Xe: a compartmental model
Author(s) -
Lavini Cristina,
Payne Geoffrey S.,
Leach Martin O.,
Bifone Angelo
Publication year - 2000
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/1099-1492(200006)13:4<238::aid-nbm633>3.0.co;2-5
Subject(s) - xenon , perfusion , respiration , chemistry , biomedical engineering , nuclear medicine , medicine , cardiology , anatomy , organic chemistry
There is an increasing interest in the use of hyperpolarized 129‐xenon (HpXe) NMR for the measurement of tissue perfusion. In this paper we present a theoretical study designed to assess the merit of intravenous HpXe delivery compared with the existing respiration techniques. A compartmental model was created to describe the behavior of the injected bolus in the circulatory system and in the lungs. The dependence of the tissue concentration on the T 1 and solubility of the Xe in the various compartments, and on injection rate, were evaluated. By this process the critical loss mechanisms are identified. It is shown that the predicted tissue concentrations of HpXe in gray and white matter are comparable using respiration or injection techniques. Copyright © 2000 John Wiley & Sons, Ltd.