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3 He‐MRI‐based measurements of intrapulmonary p O2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations
Author(s) -
Deninger Anselm J.,
Eberle Balthasar,
Ebert Michael,
Grossmann Tino,
Hanisch Gorden,
Heil Werner,
Kauczor HansUlrich,
Markstaller Klaus,
Otten Ernst,
Schreiber Wolfgang,
Surkau Reinhard,
Weiler Norbert
Publication year - 2000
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/1099-1492(200006)13:4<194::aid-nbm643>3.0.co;2-d
Subject(s) - reproducibility , nuclear medicine , apnea , partial pressure , nuclear magnetic resonance , medicine , relaxation (psychology) , paramagnetism , oxygen , chemistry , physics , chromatography , organic chemistry , quantum mechanics
We applied a recently developed method of following the time course of the intrapulmonary oxygen partial pressure p O2 ( t ) during apnea by 3 He MRI to healthy volunteers. Using two imaging series with different interscan times during two breathholds (double acquisition technique), relaxation of 3 He due to paramagnetic oxygen and depolarization by RF pulses were discriminated. In all four subjects, the temporal evolution of p O2 was found to be linear, and was described by an initial partial pressure p 0 and a decrease rate R . Also, regional differences of both p 0 and R were observed. A correlation between p 0 and R was apparent. Finally, we discuss limitations of the double acquisition approach. Copyright © 2000 John Wiley & Sons, Ltd.