High‐field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour | Zendy

Lemaire L. | Zendy; Franconi F. | Zendy; SaintAndré J. P. | Zendy; Roullin VG. | Zendy; Jallet P. | Zendy; Le Jeune JJ. | Zendy

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High‐field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour

Author(s) -

Lemaire L.,

Franconi F.,

SaintAndré J. P.,

Roullin VG.,

Jallet P.,

Le Jeune JJ.

Publication year - 2000

Publication title -

nmr in biomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 114

eISSN - 1099-1492

pISSN - 0952-3480

DOI - 10.1002/1099-1492(200005)13:3<116::aid-nbm616>3.0.co;2-d

Subject(s) - magnetization transfer , nuclear magnetic resonance , effective diffusion coefficient , brain tissue , nuclear medicine , relaxation (psychology) , diffusion , contrast (vision) , necrosis , chemistry , magnetic resonance imaging , pathology , physics , medicine , anatomy , radiology , optics , thermodynamics

The potential of quantitative parameter images of transverse relaxation time T 2 , apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) to characterize experimental brain tumours was studied. Necrosis or haemorrhage can be detected using either MTR, ADC or T 2 (necrosis—MTR reduced by 35%, ADC and T 2 increased respectively by 170% and 100% compared with normal brain tissue; haemorrhage—MTR increased by 60%, ADC and T 2 decreased by 40% and 20%, respectively). Normal brain tissue can only be distinguished from tumour on T 2 and MTR parameter images. However, for small tumours (10 µl), the best contrast is observed with MTR, ca. 30%, whereas for T 2 the contrast is ca. 10%. Copyright © 2000 John Wiley & Sons, Ltd.

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