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High‐field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour
Author(s) -
Lemaire L.,
Franconi F.,
SaintAndré J. P.,
Roullin VG.,
Jallet P.,
Le Jeune JJ.
Publication year - 2000
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/1099-1492(200005)13:3<116::aid-nbm616>3.0.co;2-d
Subject(s) - magnetization transfer , nuclear magnetic resonance , effective diffusion coefficient , brain tissue , nuclear medicine , relaxation (psychology) , diffusion , contrast (vision) , necrosis , chemistry , magnetic resonance imaging , pathology , physics , medicine , anatomy , radiology , optics , thermodynamics
Abstract The potential of quantitative parameter images of transverse relaxation time T 2 , apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) to characterize experimental brain tumours was studied. Necrosis or haemorrhage can be detected using either MTR, ADC or T 2 (necrosis—MTR reduced by 35%, ADC and T 2 increased respectively by 170% and 100% compared with normal brain tissue; haemorrhage—MTR increased by 60%, ADC and T 2 decreased by 40% and 20%, respectively). Normal brain tissue can only be distinguished from tumour on T 2 and MTR parameter images. However, for small tumours (10 µl), the best contrast is observed with MTR, ca. 30%, whereas for T 2 the contrast is ca. 10%. Copyright © 2000 John Wiley & Sons, Ltd.