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An imidazoline pseudodipeptide suitable for solid phase peptide synthesis
Author(s) -
Jones Raymond C.F.,
Dickson James
Publication year - 2000
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/1099-1387(200012)6:12<621::aid-psc298>3.0.co;2-1
Subject(s) - imidazoline receptor , solid phase synthesis , peptide , combinatorial chemistry , chemistry , peptide synthesis , phase (matter) , pharmacology , medicine , biochemistry , organic chemistry
This paper describes the synthesis of two diastereoisomers of an imidazoline dipeptide mimetic (a 4,5‐dihydroimidazole‐4‐carboxylic acid), suitably protected for incorporation into solid phase peptide synthesis (SPPS) using the Fmoc protocol, from a phenylalanine‐derived thioimidate and an α,β‐diaminopropanoic acid ester, followed by protecting group manipulation. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.