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An efficient solid‐phase strategy for the construction of chemokines 1
Author(s) -
Mcnamara John F.,
Lombardo Holly,
Pillai Sasi K.,
Jensen Ivar,
Albericio Fernando,
Kates Steven A.
Publication year - 2000
Publication title -
journal of peptide science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 66
eISSN - 1099-1387
pISSN - 1075-2617
DOI - 10.1002/1099-1387(200010)6:10<512::aid-psc269>3.0.co;2-a
Subject(s) - chemokine , solid phase synthesis , combinatorial chemistry , coupling (piping) , phase (matter) , computer science , chemistry , biological system , nanotechnology , materials science , biology , organic chemistry , biochemistry , composite material , peptide , receptor
Synthesis of chemokines via stepwise SPPS approaches has been shown to be a challenge. Herein, a complete study of different coupling methods, solvents and temperature combined with a continuous‐flow synthesizer equipped with feedback monitoring was carried out. The results from this study indicate that this family of molecules can be prepared using an Fmoc/Bu t chemical approach and provide a general method to apply for the elongation of other difficult sequences. Copyright © 2000 European Peptide Society and John Wiley & Sons, Ltd.