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Synthesis of a 11 C‐labelled prostaglandin F 2α analogue using an improved method for stille reactions with [ 11 C]methyl iodide
Author(s) -
Björkman Margareta,
Doi Hisashi,
Resul Bahram,
Suzuki Masaaki,
Noyori Ryoji,
Watanabe Yasuyoshi,
Långström Bengt
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(200012)43:14<1327::aid-jlcr419>3.0.co;2-d
Subject(s) - chemistry , methyl iodide , iodide , stille reaction , radiochemistry , yield (engineering) , isopropyl , nuclear chemistry , iodine , medicinal chemistry , organic chemistry , catalysis , materials science , metallurgy
17‐(3‐[ 11 C]methylphenyl)‐18,19,20‐trinor‐PGF 2α isopropyl ester 2 was synthesised using an improved method for cross‐coupling reactions with [ 11 C]methyl iodide. The decay‐corrected radiochemical yield of 2 was 34 % based on [ 11 C]methyl iodide in a synthesis time of 30 min from end of radionuclide production. The specific radioactivity was approximately 100 GBq/µmol and the radiochemical purity was higher than 95 % as determined by analytical LC. In a typical experiment 1.3 GBq of 2 was obtained from 11 GBq of [ 11 C]methyl iodide. Copyright © 2000 John Wiley & Sons, Ltd.