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Samarium iodide mediated methylation: an alternative to grignard labeling
Author(s) -
Landvatter Scott W.
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(200012)43:14<1321::aid-jlcr418>3.0.co;2-m
Subject(s) - chemistry , samarium , iodide , methylation , grignard reaction , radiochemistry , organic chemistry , biochemistry , reagent , gene
Samarium iodide in THF/HMPA has been used to methylate various aldehydes and ketones in moderate to good yield. Reaction is complete within two minutes. Labeling using methyl‐[ 14 C] iodide has been successful and is thus an alternative to labeling via a methyl Grignard derived from methyl‐[ 14 C] iodide. Copyright © 2000 John Wiley & Sons, Ltd.