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Syntheses of two [ 14 C]‐labeled disodium 4‐[( N ‐tert‐butylimino)methyl]benzene‐1,3‐disulfonate N ‐oxides
Author(s) -
Johansson Rolf,
Werner Tom
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(200011)43:13<1265::aid-jlcr415>3.0.co;2-m
Subject(s) - chemistry , benzene , carbon 14 , chemical synthesis , medicinal chemistry , stroke (engine) , combinatorial chemistry , in vitro , organic chemistry , biochemistry , mechanical engineering , engineering , physics , quantum mechanics
NXY‐059 ( 5 ) is a new chemical entity developed as a putative agent for the treatment of acute and chronic neurological degenerative disorders. It is currently undergoing clinical evaluation for the treatment of stroke. In order to study the metabolic transformation and organ distribution of the compound, radiolabeled NXY‐059 was needed. In this paper, we describe the synthesis of two differently carbon‐14 labeled disodium 4‐[( N‐tert ‐butylimino)methyl]benzene‐1,3‐disulfonate N ‐oxides. Copyright © 2000 John Wiley & Sons, Ltd.