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Effect of Concomitant 18 O in 13 C‐Urea on the Urea breath test
Author(s) -
Maruyama Wataru,
Mori Masami,
Sato Rie,
Kajiwara Masahiro,
Kimura Ken
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(20001015)43:11<1113::aid-jlcr397>3.0.co;2-m
Subject(s) - chemistry , urea , δ18o , mass spectrometry , carbon dioxide , urea breath test , mass spectrum , stable isotope ratio , chromatography , helicobacter pylori , organic chemistry , helicobacter pylori infection , medicine , physics , quantum mechanics
Helicobacter pylori infection in stomach has been extensively assessed by the 13 C‐urea breath test (UBT) with infra‐red or mass spectrometer. However, analyses of commercially available 13 C‐urea for UBT showed about 10 atom% of 18 O abundance. It is therefore very important to investigate the 18 O‐isotope effect on UBT. Using a mass spectrometer, breath samples of UBT were analyzed to investigate the change of mass spectra by the isotopic exchange reaction between 18 O of carbon dioxide and 16 O of water. As the result, the 18 O content of 13 C, 18 O‐carbon dioxide exhaled in UBT reached its natural abundance level immediately after the administration of 13 C, 18 O‐urea. It was concluded that the 18 O content of 13 C, 18 O‐urea has no effect on UBT using either infra‐red or mass spectroscopy. Copyright © 2000 John Wiley & Sons, Ltd.