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Synthesis of 5,5‐dimethyl‐1‐pyrroline‐N‐oxide‐2‐ 14 C
Author(s) -
Le Diem Duy,
Zhang Yinsheng,
Nguyen Danh,
Moravek Josef
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(20001015)43:11<1107::aid-jlcr396>3.0.co;2-o
Subject(s) - chemistry , pyrroline , combinatorial chemistry , oxide , medicinal chemistry , organic chemistry
5,5‐Dimethyl‐1‐pyrroline‐ N ‐oxide‐ 2 ‐ 14 C arrived via coupling of 2‐nitropropane with labelled acrylate instead of acrolein. The new alternate step is safer, more convenient and efficient for 14 C‐labelling. The radioactive spin trap has a sp. activity of 13 mCi/mmol, >98% purity, and shows no degradation after two months at −80°C in neat form. Copyright © 2000 John Wiley & Sons, Ltd.