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Synthesis of 1‐[2‐[ 18 F]fluoro‐1‐(hydroxymethyl)‐ethoxy]methyl‐2‐nitroimidazole ([ 18 F]FENI), a potential agent for imaging hypoxic tissues by PET
Author(s) -
Wada Hiroaki,
Iwata Ren,
Ido Tatsuo,
Takai Yoshihiro
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(200007)43:8<785::aid-jlcr363>3.0.co;2-5
Subject(s) - chemistry , hydroxymethyl , nitroimidazole , alkoxy group , toluene , pet imaging , high performance liquid chromatography , nuclear chemistry , radiochemistry , stereochemistry , chromatography , organic chemistry , positron emission tomography , nuclear medicine , alkyl , medicine
Fluorine‐18 labeled 1‐[2‐fluoro‐1‐(hydroxymethyl)ethoxyl]‐methyl‐2‐nitroimidazole ([ 18 F]FENI), a novel, potential radiotracer for imaging hypoxic tissue by PET, was synthesized. The [ 18 F]FENI was prepared by nucleophilic 18 F‐fluorination of the precursor. 1‐[2‐toluene‐4‐sulfoxy)‐1‐(acetoxymethyl)ethoxy]methyl‐2‐nitroimidazole, followed by deprotection and HPLC purification. Radiochemically pure [ 18 F]FENI was obtained in overall yields of 3–11% (EOB) with specific activity of >26 GBq/μmol (EOS) within 90 min. Copyright © 2000 John Wiley & Sons, Ltd.