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Synthesis of [25,26,26,26,27,27,27‐d 7 ]‐cholesterol
Author(s) -
Chu GuoHua,
Li PuiKai
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(200007)43:8<773::aid-jlcr361>3.0.co;2-g
Subject(s) - chemistry , stigmasterol , aldehyde , yield (engineering) , cholesterol , sequence (biology) , stereochemistry , chemical synthesis , combinatorial chemistry , organic chemistry , chromatography , biochemistry , in vitro , catalysis , materials science , metallurgy
An efficient synthesis of [25, 26, 26, 26, 27, 27, 27‐d 7 ]‐cholesterol 1 , a useful tool for the measurement of cholesterol absorption, is described. Commercially available stigmasterol is converted into the known aldehyde 2 which was then transformed to the d 7 ‐cholesterol 1 through a reaction sequence of 8 steps in an overall yield of 22·5%. Copyright © 2000 John Wiley & Sons, Ltd.