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Synthesis of deuterium labelled benomyl and carbendazim residue standards
Author(s) -
Zimmerman William T.
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(200007)43:8<767::aid-jlcr360>3.0.co;2-i
Subject(s) - chemistry , carbendazim , benzimidazole , benomyl , deuterium , residue (chemistry) , ring (chemistry) , aqueous solution , radiochemistry , medicinal chemistry , organic chemistry , fungicide , botany , physics , quantum mechanics , biology
Three environmental degradation products of benomyl possessing tetradeutero‐ring substitutions were synthesized for use in quantitative analysis of trace residues. The common precursor, 1,2‐phenylene‐diamine, was exhaustively deuterated upon heating in acidic aqueous media. Further synthetic transformations to 2‐aminobenzimidazole‐4,5,6,7‐ 2 H 4 , carbendazim‐4,5,6,7‐ 2 H 4 , and 3‐butyl‐1,3,5‐triazino‐[1.2a]benzimidazole‐2,4(1H,3H)‐dione‐6,7,8,9‐ 2 H 4 proceeded with complete retention of the ring substituted deuterium. Copyright © 2000 John Wiley & Sons, Ltd.