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Screening catalysts for the catalytic exchange of hydrogen by tritium using magnetic labeling
Author(s) -
Niessen Heiko G.,
Ulrich Claudia,
Bargon Joachim
Publication year - 2000
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/1099-1344(200006)43:7<711::aid-jlcr356>3.0.co;2-q
Subject(s) - chemistry , tritium , catalysis , hydrogen , radiochemistry , combinatorial chemistry , organic chemistry , nuclear physics , physics
Isotope labeling is an important method to evaluate drugs and compounds for agricultural use. Therefore, a fast and convenient method to selectively exchange hydrogen against non‐radioactive deuterium or radioactive tritium in the final product is desirable. PHIP‐NMR investigations of the influence of CO on the selective exchange of the geminal protons in styrene show that CO increases the efficiency of the selective exchange non‐linearly and suppresses the hydrogenation of styrene to ethylbenzene. Copyright © 2000 John Wiley & Sons, Ltd.