Premium
Organosulfur compounds as pre‐exposure therapy for threat agents
Author(s) -
Ternay A. L.,
Brzezinska E.,
Sorokin V.,
Cook C.,
Lyaschenko Yu. E.
Publication year - 2000
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/1099-1263(200012)20:1+<::aid-jat692>3.0.co;2-p
Subject(s) - organosulfur compounds , benzothiazole , thiol , disulfide bond , chemistry , hydrochloride , cyanide , combinatorial chemistry , sulfur , enzyme , organic chemistry , biochemistry
A series of symmetric (Ar‐S‐S‐Ar) and unsymmetric (Ar‐S‐S‐CH 2 CH 2 NH 3 +Cl − ) disulfides have been prepared and evaluated as potential cyanoprotective agents. Target compounds have been prepared by known methods and/or methods developed by us specifically for this program, e.g. reaction of a thiol with 2,2′‐dithiobis(benzothiazole) (BT‐S‐S‐BT) followed by reaction with a second thiol. Both 4‐methoxyphenyl disulfide and 2‐aminoethyl‐4‐methoxyphenyl disulfide hydrochloride are cyanoprotective against 2‐ ld 50 of injected cyanide. Evaluation of both symmetric and unsymmetric related disulfides indicates that structural requirements for cyanoprotective activity are stringent and strongly suggest that protection is enzyme mediated. In addition to cyanoprotective action, initial results suggest that unsymmetric disulfides may evolve into effective antimustard agents. Copyright © 2000 John Wiley & Sons, Ltd.