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Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure
Author(s) -
Nagaraj M.,
Sunitha S.,
Varalakshmi P.
Publication year - 2000
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/1099-1263(200009/10)20:5<413::aid-jat706>3.0.co;2-y
Subject(s) - lupeol , cadmium , lipid peroxidation , antioxidant , cadmium chloride , chemistry , pharmacology , nephrotoxicity , kidney , triterpene , toxicity , body weight , toxicology , biochemistry , endocrinology , medicine , biology , pathology , organic chemistry , alternative medicine
This study pertains to the role of lupeol, a pentacyclic triterpene, against the toxic manifestations of chronic cadmium exposure. Cadmium is a potent nephrotoxin on prolonged exposure. Cadmium (as cadmium chloride) at a dose of 1 mg kg −1 body weight was administered subcutaneously for 15 days to rats. This led to an increase in the level of lipid peroxides and a decrease in the level of antioxidants in the kidney. Lupeol, when supplemented at a dosage of 40 mg kg −1 body weight concurrent with cadmium administration, showed an improvement in the antioxidant status. The level of lipid peroxides also showed a significant decrease, which shows the nephroprotective action of the drug Copyright © 2000 John Wiley & Sons, Ltd.