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Diet and the aetiology of temporal advances in human and rodent sexual development
Author(s) -
Ashby J.,
Tinwell H.,
Odum J.,
Kimber I.,
Brooks A. N.,
Pate I.,
Boyle C. C.
Publication year - 2000
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/1099-1263(200009/10)20:5<343::aid-jat719>3.0.co;2-o
Subject(s) - toxicology , biology
2. Estrogenic activity can be assayed by measuring increases in uterine weight (“uterotrophic activity”) in immature or ovariectomised rodents. These models are used as they have low or no production of endogenous estrogens and are therefore, more sensitive to the administration of exogeneous estrogens. Advances in the age at which vaginal opening or first oestrus occurs in rodents is also used as an assay for exogeneous estrogens.