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Use of donepezil for the treatment of mild – moderate Alzheimer's disease: an audit of the assessment and treatment of patients in routine clinical practice
Author(s) -
Cameron Ian,
Curran Stephen,
Newton Paul,
Petty Duncan,
Wattis John
Publication year - 2000
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/1099-1166(200010)15:10<887::aid-gps212>3.0.co;2-m
Subject(s) - donepezil , discontinuation , medicine , disease , clinical trial , clinical practice , dementia , placebo , alzheimer's disease , audit , pediatrics , intensive care medicine , psychiatry , physical therapy , alternative medicine , management , pathology , economics
There have been a number of randomised, placebo‐controlled trials of donepezil in the treatment of mild – moderate Alzheimer's disease and these report significant benefits for a proportion of patients. Little is known about the use of donepezil in routine clinical practice. The aims of this study were to examine the use of donepezil in routine clinical practice and to identify some of the practical and resource implications associated with treatment. A number of areas were examined against published guidelines including assessment, diagnosis, initiation of treatment, monitoring and discontinuation of treatment. This was a retrospective case note study involving patients with mild – moderate Alzheimer's disease over a one‐year period. One hundred and seventeen patients were commenced on donepezil and 93 successfully completed three months of treatment. Of these, 47% demonstrated an improvement in cognition, activities of daily living or carer observation (or a combination). Compliance with accepted guidelines with respect to assessment, diagnosis and monitoring requires a standardised approach that has both clinical and resource implications. Copyright © 2000 John Wiley & Sons, Ltd.