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A review of the role of serotonin receptors in psychiatric disorders
Author(s) -
Naughton Marie,
Mulrooney Jane B.,
Leonard Brian E.
Publication year - 2000
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/1099-1077(200008)15:6<397::aid-hup212>3.0.co;2-l
Subject(s) - serotonergic , serotonin , psychosis , anxiety , psychiatry , depression (economics) , migraine , receptor , psychology , neuroscience , medicine , economics , macroeconomics
Abstract Serotonin (5‐hydroxytryptamine, 5‐HT) mediates a wide variety of physiological functions by activating multiple receptors, and abnormalities of these receptor systems has been implicated in many psychiatric disorders including anxiety, depression, psychosis, migraine, disorders of sexual functioning, sleep, cognition, and feeding. Many of the currently used treatments for these disorders act by affecting the serotonergic system. Observation of serotonin receptor alterations, before and following effective treatments, may yield important insights into the aetiology of these psychiatric disorders and may ultimately lead to more selective and effective therapies. Copyright © 2000 John Wiley & Sons, Ltd.